Mouse blastocyst with trophectoderm (TE), epiblast (EPI) and primitive endoderm (PE) from Selenka 1883 |
Gene expression in these three lineages of mouse placenta has been known for some time. What does this tell us about human preimplantation development? A recent paper in Development (here) suggests less than some might like to think.
- For trophectoderm, key lineages expressed in the mouse (e.g. Id2, Elf5, Eomes) either are not expressed in human trophectoderm or are expressed in alternative lineages.
- There are several genes that are exclusively expressed in human epiblast (e.g.the transcription factor KLF17).
- Expression of some genes in primitive endoderm is conserved between mouse and human (e.g. Foxa2/FOXA2).
These findings support other work indicating that the genes and signalling pathways involved in lineage specification differ between mouse and human blastocysts.
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