|Anopheles stephensi - a vector for the malaria parasite|
Centers for Disease Control and Prevention
|Placenta from a stillbirth due to maternal malaria infection. Normal erythrocytes lack |
a nucleus. Thus a nucleus indicates the presence of the malaria parasite.
Wikimedia Commons (CC BY-SA 3.0) uploaded by Nephron
A paper just out in Cancer Cell (here) shows that placental CSA is expressed by many types of cancer cell. This knowledge was leveraged to target cancer cells using recombinant VAR2CSA fused to diptheria toxin or conjugated to hemiasterlin. Human cancer cells in vitro were effectively killed by this means. Tumour growth and metastasis in mice could be inhibited by a similar approach.